On Preparation and in-Vitro Release of the Guaifenesin Sustained-Release Tablets
LU Nan
TIAN Jingjing
SHENG Furong
CHEN Yibo
ZHAO Hongli
Abstract：Objective To prepare the guaifenesin sustained-release tablets, and evaluate its release in vitro. Methods The prescription was optimized by orthogonal experiment with guaifenesin as model drug and HPMC as the skeleton material. The in-vitro release of guaifenesin sustained-release tablets was observed and analyzed by ultraviolet spectrophotometry with water as medium. Re-sults The prescription included 40 g guaifenesin, 11 g HPMC, 15 g microcrystalline cellulose, 20% povidone-ethanol solution and 1% magnesium stearate. The content and release in vitro were both up to standard. Conclusion This prescription and craft design are reasonable, and the release in vitro is accorded with the requirement of 90% cumulative release of sustained-release tablets in 12 hours.
Keywords：guaifenesinsustained-release tabletsrelease
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )