Clinical Efficacy of Combined Usage of Mosapride and Hydrotclcire for Patients with Bile Reflux Gastritis

LIANG Yanxing; DENG Zhiming

Abstract：Objective To evaluate the clinical efficacy of combined usage of mosapride and hydrotclcire for bile reflux gastritis. Methods 60 cases of RBG patients treated in our hospital from October 2010 to October 2014 were randomly divided into control group given mosapride and combined treatment group given mosapride and hydrotclcire.Such treatment results as clinical efficacy, bile reflux, clinical symptom scores and adverse reactions were compared between these two groups.Results The treatment efficiency of combined treatment group (93.8%) was significantly higher than that of the control group (71.4%).The difference was statistically significant (χ2 =7.090, P<0.05); In the combined treatment group, the reflux episodes, reflux episodes ( >5 min) and the per-centile index of total reflux time were lower than the control group (t =-4.072, -8.416, -5.256, P<0.01).Also the nausea scores, abdominal pain scores, and bloating scores were lower than the control group (t =-9.247, -2.833, 8.390, P<0.05). However, there was no difference between the two groups in the longest reflux time and vomiting scores (t =-1.872, 1.767, P>0.05), there was no statistically significant difference in incidence of adverse reaction (χ2 =3.202, P>0.05).Conclusions The combination usage of mosapride and hydrotclcire can conjugate bile reflux, promote gastrointestinal motility and cause fewer adverse re-actions, and therefore it is applicable for RBG patients.