The Curative Effects of GnRH-a Assisted Laparoscopic Resection for Bilateral Ovarian Endometriosis Cyst on Ovarian Reserve

PENG Lizhen; OU Shaoling

Abstract：Objective To investigate the curative effects of GnRH-a assisted laparoscopic resection for bilateral ovarian endome-triosis cyst and its influence on the second pregnancy. Methods 64 cases of bilateral ovarian endometriosis cyst were randomly select-ed and divided into the intervention group (n=34) and the conventional group (n=30). The intervention group was given GnRH-a 3. 75 mg injection for 2 weeks, then underwent laparoscopic excision for endometriosis cyst, while the conventional group was not giv-en any pretreatment and simply given laparoscopic surgical treatment, then the change of hormone levels and ovarian diameters were compared between the two groups after treatment, and both group received the follow-up for 1 year, then the pregnancy and cyst re-currence were compared. Results The FSH level of the intervention group were (8. 03+2. 11) mIU /mL, significantly lower than the conventional group, while the E2 and LH levels were higher than conventional group with significant difference (P<0. 05), normal o-vary diameter less than 2 cm accounted for 67. 65%, and ovarian volume was significantly reduced; after 1 year of follow-up, the cyst recurrence rate of the intervention group was 5. 88%, pregnancy rate was 63. 63%, and the postoperative pregnancy interval in-terval time was shortened with statistically significant difference compared with the conventional group (P<0. 05). Conclusion Appli-cation of GnRH-a before laparoscopic bilateral ovarian endometriosis cyst surgery can effectively reduce the influence on the ovarian re-serve function as much as possible and effectively protect the ovarian function for the patients who have the reproduction requirements.