Clinical Observation of Raltitrexed Combined with Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastases
LIU Xing
XUE Haiou
ZHANG Chunmei
Abstract：Objective To investigate the clinical efficacy and safety of raltitrexed combined with oxaliplatin in the treatment of colorectal cancer liver metastases after failure in first-line treatment. Methods A total of 39 colorectal cancer patients with liver me-tastases were treated by raltitrexed and oxaliplatin after they failed in FOLFOX, 1FOLFIRI or XELOX. They were given oxaliplatin, 130 mg/m2 ivgtt, d1; raltitrexed, 3mg/ m2 ivgtt, d2 and cold insulation care, d3, with 21 days as a cycle, until there was evi-dence of disease progression or intolerance in the treatment. Results After the combined treatment of raltitrexed and oxaliplatin, RR reached 28. 2%, and DCR was 76. 9%. The main side effects were nausea and vomiting, elevated transaminase and peripheral neuro-toxicity with incidence rates of 56. 4%, 48. 7% and 46. 2% respectively. Conclusion The treatment method, raltitrexed combined with oxaliplatin, after the failure in FOLFOX, FOLFIRI or XELOX proves to effective for colorectal cancer patients with liver metasta-ses, with tolerance to toxicity.
Keywords：raltitrexedoxaliplatincolorectal cancerhepatic metastasis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 29-31 )