The Changes of Serum Apelin Level in Elderly Patients with Metabolic Syndrome and its Correlation Analysis
FANG Fang
HU Youzhuang
ZHENG Guifeng
WANG Junxian
CHEN Kai
Abstract：Objective To investigate the changes of the Apelin level in elder patients with metabolic syndrome and analyze the correlation between Apelin and insulin resistance. Methods Fasting blood serum Apelin was measured in 110 cases, 80 cases of old age patients with metabolic syndrome and 30 cases of the normal ( the control group) , specifically. Such data as the height, weight, waist, fasting insulin, glucose and blood lipid of these cases were measured. The old age group with metabolic syndrome were divided into two groups at the 28 point of BMI. Results (1) Serum Apelin concentration in the elderly obesity group with metabolic syn-drome and the non-obesity group was higher than that in control group [ (452. 63±20. 27, 401. 76±26. 71) vs (368. 23±18. 19) ng/L, P<0. 01]. (2) Serum Apelin concentration in in the elderly obesity group with metabolic syndrome was higher that in the non-o-besity group [ (452. 63±20. 27) vs (401. 76±26. 71) ng/L, P<0. 05]. (3) Partial correlation analysis showed that Apelin was posi-tively correlated with HOMA-IR, FINS, BMI , TG, TC, LDL and negatively correlated with HDL. Conclusion Apelin is related with obesity and insulin resistance. How to improve insulin resistance and reduce the level of serum Apelin in patients with metabolic syndrome may become new targets for drugs.
Keywords：Apelinmetabolic syndromeinsulin resistancelipid
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 10-12 )