Synthesis of Methyl 3-formyl-1-methyl-1 H-indole-2-carboxylate
WU Zhuo
GUO Weiying
XIE Honglei
Abstract：Objective To synthesize methyl 3-formyl-1methyl-1H-indole-2-carboylate. Methods With 1H-indole-2-car-boxylic acid and methanol as starting material, the compound mentioned above was synthesized after esterification as well as reaction of methylation and Vilsmeier-haack, with a total yield of 90. 3%. Results This method boasted the advantages of mild reaction condi-tion, high yield, and easy purification, providing a new way of synthesis of target compound. The structure characterization of the product was completed with 1H-NMR and LC-MS. Conclusion The method has advantages of high yield, simple operation and safe-ty, with reference value for industrialized production. .
Keywords：1H-indole-2-carboxylicacidmethyl3-formyl-1-methyl-1H-indole-2-carboxylatesynthesis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )