Study on the Synthesis of Uracil as a Pharmaceutical Intermediate
WANG Limin
WANG Siyao
ZHANG Shiti
YAN Dongxue
JIA Yunhong
Abstract：Objective To improve the synthesis of uracil which is an important pharmaceutical intermediate for antiviral, antican-cer drugs, etc, and to preliminarily discuss the feasibility of urea synthetizing uracil in place of thiourea. Methods Ethyl formate and ethyl acetate were used as the starting material to synthesize the target compound by one-pot method whose structure was identified by 1 HNMR spectrometry. Results With improved technology, the yield of product reached 71%, and the purity exceeded 99%( HPLC, normalization method) . Conclusion The improved technology, simple and feasible, has reduced the cost, which is suitable for industrial production.
Keywords：uracilone-pot methodthioureaureaprogress improvement
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )