The Expression of TGF-β1 and NF-κB Protein in Gastric Cancer Tissues with HP Infection

LIU Xingyuan; MENG Hai

Abstract：Objective To explore the expression of TGF-β1 and NF-κB protein in gastric cancer tissues with HP infection and to find out the effect of HP on gastric cancer according to statistical analyses involving HP infection status and clinical pathology. Meth-ods Giemsa staining was used to detect HP infection of gastric cancer group (113 cases) and of chronic gastritis (57cases). Immu-nohistochemistry is used to detect expression of TGF-β1 and NF-κB protein in HP (+) group (88 cases) and HP (-) group (25 cases) . Results HP infection rate in chronic gastritis group was 50.9% ( 29/57 ) . HP infection rate in gastric cancer group was 77.9% (88/113), which is higher than that of the former (χ2=12.87, P<0.01) . The clinicopathological parameters showed that HP infection was not related with gender, age, tumor location, size, degree of differentiation, distant metastasis, lymph node metasta-sis (P>0.05) but related with the depth of invasion of gastric cancer tissues. Immunohistochemistry showed that TGF-β1 protein ex-pression rate in the HP (+) gastric cancer tissues ( 76.1%) was significantly higher than that in the HP (-) gastric tissues (52.0%). NF-κB protein expression in the HP (+) gastric cancer tissues (62.5%) was significantly higher than the HP (-) gas-tric tissues (40.0%). Conclusion Once the gastric tissues are infected by HP, there is the possibility that TGF-β1 and NF-κB be-come the pathway for regulating genetic transcription and signals transmission in cells, leading to the occurrence, development and me-tastasis of gastric cancer.