Effects of Metformin on Patients with Type-2 Diabetes ET-1 and Serum hs-CRP, TNF2 Levels
DENG Xiaolong
ZHU Hongxia
WANG Minzhe
Abstract：Objective To study the effects of metformin on plasma ET-1 and serum hs-CRP and TNF2 levels of patients with type-2 diabetes. Methods Radioimmunoassay and immune methods were used to detect plasma ET-1, serum HS-CRP and TNF2 levels in 33 patients with T2DM turbidimetric, compared with 35 healthy people. Results Before treatment, plasma ET-1, serum hs-CRP and TNF-2 levels of T2D2 patients were significantly higher than those healthy people (P<0.01). After metformin treatment for 3 months, there was no significant difference in plasma ET-1, serum HS-CRP and TNF2 levels of patients compared with the nor-mal (P>0.05). Plasma ET-1 levels were positively correlated with Serum hs-CRP and TNF2 levels (R=0.6184, 0.5948 P<0.01). Conclusion Metformin can improve vascular endothelial function.
Keywords：type-2 diabetesMetformin Endothelin-1 (ET-1)super C-reactive protein (hs-CRP)tumor necrosis factor 2 (TNF2)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 48-49 )