Influence of bFGF on Sorbitol Dehydrogenase Expression in Rat Mesangial Cell and Rat Thy-1 Nephritis
YUE Lingjv
Abstract：Objective To investigate the influence of the basic fibroblast growth factor ( bFGF) on sorbitol dehydrogenase ( SDH) expression of rat mesangial cells ( MsC) and rat anti Thy-1 glomerular nephritis models. Methods The mesangial cells ( MsC) were cultured by sterile methods. The SDH expression in MsC was detected by western blot methods and meanwhile the expression of bFGF and SDH got detected in ATC. Results MsC became fibroblast- like cells. The SDH expression was higher than normal after exoge-nous bFGF was induced and in a time-dose dependent trend. For the ATC, with the prolongation of disease course, the expression of bFGF and SDH were raised in protein level. Conclusions The bFGF can up-regulate the SDH expression. The SDH can participate in the progress of occurrence and developments of Thy-1 glomerular nephritis.
Keywords：glomerular nephritisbasic fibroblast growth factorsorbitol dehydrogenase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 4-7 )