The Correlation Between HPV Infection and Protein Expression of Rb and Mcl-1 in Non-small Cell Lung Cancer
LIU Xingyuan
QI Fengjie
Abstract：Objective To study the relationship between HPV ( Human papillomavirus, HPV) infection, the expression of Rb&Mcl-1 protein and the non-small cell lung cancer ( Non-small-cell Lung Cancer, NSCLC) . Methods PCR and Immunohistochemis-try (IHC) were used to detect HPV DNA expression and protein expression of Rb and Mcl-1 in NSCLC group (79 cases) and benign lung lesion group (11 cases). Results The positive rate of HPV in NSCLC group is 46.8% , and the positive rate of HPV in lung benign lesion group is 9.1% (P<0.05). HPV positive expression is related to histological type, degree of differentiation and smoking. Rb protein positive expression in HPV-positive group ( 37.8%) is significantly lower than the negative group ( 61.9%) in NSCLC ( P<0.05 ) . Mcl-1 protein positive expression in HPV-positive group ( 59.5%) is significantly lower than the negative group (35.7%) in NSCLC (P<0.05). In benign lesion group, the rate of Rb protein expression is 72.7%, but Mcl-1 protein is not ex-pressed. Conclusion Development of NSCLC is related to HPV infection by inhibiting the Rb protein pathway and promoting Mcl-1 protein pathway.
Keywords：NSCLCHPVRb proteinMcl-1 protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-3,7 )