Study on the Expression of The Expression of PTTG Gene in Patients with Non-Hodgkin Lymphoma
DONG Huali
LI Daqi
CHEN Ping
SHAO Jianhua
ZHAO Hongyu
Abstract：Objective To explore the expression of PTTG in patients with non-Hodgkin's lymphoma ( NHL), its relationship with NHL and its clinical significance.Method PTTG gene expression on bone marrow mononuclear cell (BMMNC) in 32 patients with non-hodgkin Lymphoma (NHL) and 10 patients with chronic lymphadenitis were detected by RT-PCR method. Results 18 of 32 (56.3%) cases with NHL were observed with PTTG gene expression, among which there were peripheral T cell lymphoma 55.6%(5/9 cases), 56.5% (13/23 cases) of diffuse large B cell lymphoma.PTTG gene expression levels of patients with NHL were significantly higher than those in patients with chronic lymphadenitis ( P<0.05 ) .PTTG gene expression difference in patients with peripheral T cell lymphoma and in patients with diffuse large B cell lymphoma is of no statistical significance ( P>0.05 ) .Conclu-sion The overexpression of PTTG gene may be related to the occurrence and development of lymphoma .
Keywords：lymphomanon-HodgkinPTTGreverse transcriptase-polymerase chain reactiongene expression
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 6-8,108 )