Effect of Oxria cetam on Exper ssiono f Bcl-2 and Bax in Rats with Cerebral Ischemia-reperfusion Injury
ZHAO Yujiao
MA Fengjie
LI Fang
WU Chunyan
DOU Shoutan
Abstract：Objective To investigate the effect of Oxiracetam on protein expression of Bcl-2 andBax in rats with cerebral ische-mia-reperfusion injury.Methods Rat ischemia-reperfusion model was established by using the middle cerebral artery suture method, rats were randomly divided into the shamoperative group,the saline group, the high-dose Oxiracetam group and the low-dose Oxirace-tamgroup .The Bcl-2 and Baxprotein expression were detected by using immunohistochemistry assay after 24hof reperfusion in rat brain tissue. Results Compared with thesham operative group, the rats'Bcl-2 and Bax protein expression was significantly in-creased in the saline group (P<0.01), compared with the saline group, the rats'Bcl-2 expressionwas significantlyhigher in the drug group (P<0.01 ), and the Bax expression was significantly reduced (P<0.01), compared with low-dose Oxiracetam group, the rats’ Bcl-2 expression increased (P<0.05), and the Bax expression decreased (P<0.05) in high-doseOxiracetam group.Conc lu-sion The expression of Bcl-2 and Bax were enhanced after focal cerebral ischemia and reperfusion.Oxiracetam can play a protective role inthe brain by up-regulating the Bcl-2 protein and down-regulating the Bax protein.
Keywords：oxiracetamcerebral ischemia and reperfusionBcl-2Bax
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-2,26 )