Influencing factors of central line-associated bloodstream infection in ICU patients:a scoping review
WANG Zhe
ZHANG Yuxia
HU Yan
LI Chunlei
YANG Mayi
HE Xiaofeng
ZHOU Tianjun
Abstract：Objective:To conduct a scoping review of studies regarding the influencing factors of central line-associated bloodstream infection in ICU patients.Methods:According to the scoping review framework developed by Arksey and O'Malley and following the"5S"pyramid model of evidence-based resources,a top-down search was conducted across the following databases:BMJ Best Practice,the Guidelines International Network(GIN),the National Guideline Clearinghouse(NGC),the National Institute for Health and Care Excellence(NICE)guidelines repository,the Scottish Intercollegiate Guidelines Network(SIGN),the Registered Nurses'Association of Ontario(RNAO),Medlive,the Joanna Briggs Institute(JBI)Evidence-Based Healthcare Center,PubMed,Web of Science,the Cochrane Library,CINAHL,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Chinese Science and Technology Journal Database,and the China Biology Medicine disc(CBM).The literature types included clinical practice guidelines,evidence summaries,best practice recommendations,practice recommendations,systematic reviews,and original studies.The search period was set from January 1,2019,to September 30,2024.Both Chinese and English literature were searched and screened,followed by data extraction and synthesis of the included studies.Results:A total of 22 studies from 22 countries were adopted,including 4 guidelines,1 practice recommendation,2 expert consensuses,1 evidence summary,3 systematic reviews and 11 original studies.Literature analysis indicates that the factors influencing the occurrence of central line-associated bloodstream infections in ICU patients include:demographic characteristics;disease-,treatment-,and hospitalization-related factors;catheter insertion factors;aseptic techniques during catheter maintenance;and the operational practices of healthcare staff during maintenance,etc.Conclusions:The influencing factors of central line-associated bloodstream infection in ICU patients were found to include 6 aspects,which are complex and diverse.In the future,medical institutions can optimize the monitoring indicators for central line-associated bloodstream infection based on the above influencing factors.Among these factors,the operational practices of healthcare staff are relatively more amenable to intervention.Hospitals should enhance supervision,standardize catheter operation procedures,and improve the skill level and professional competence of ICU medical personnel to reduce the incidence of central line-associated bloodstream infections in ICU patients.
Keywords：intensive care unitICUcentral line-associated bloodstream infectionscoping review
Publication Date：2026-02-25
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：7( 648-654 )