Potential profile analysis and influencing factors of peripheral neuropathy caused by chemotherapy in lung cancer patients
YAO Li
DING Min
ZHONG Sijia
TANG Li
LIU Zilong
WU Yan
Abstract：Objective:To explore the potential subtypes of peripheral neuropathy caused by chemotherapy in lung cancer and analyze the influencing factors of different subtypes.Methods:A purposive sampling method was used to select A total of 315 lung cancer patients who underwent taxane chemotherapy at Affiliated Zhongshan Hospital of Fudan University from January 2023 to June 2024 as the study subjects.A questionnaire survey was conducted using a General Information Questionnaire and the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool(CIPNAT).Statistical analysis of potential profile types was performed using R language 4.3.2 software.Univariate analysis and multivariate logistic regression were used to explore the influencing factors of different subtypes.Results:Peripheral neuropathy caused by chemotherapy in lung cancer could be divided into two potential profiles:a low-response group(81.59%)and a high-response group(18.41%).Univariate analysis showed statistically significant differences in gender,insomnia,hypertension,number of chemotherapy sessions,hemoglobin levels,living arrangements,fatigue,and the use of single-drug/double-drug chemotherapy(P<0.05).Multivariate logistic regression analysis revealed that gender,insomnia,hypertension,and number of chemotherapy sessions were influencing factors for different subtypes of peripheral neuropathy induced by lung cancer chemotherapy.Conclusion:There is significant heterogeneity among patients with peripheral neuropathy induced by lung cancer chemotherapy.Healthcare professionals should pay attention to the peripheral neuropathy status of lung cancer chemotherapy patients,develop personalized intervention strategies based on the influencing factors of different subtypes,implement precise treatment and nursing care,continuously improve the neuropathy symptoms of lung cancer chemotherapy patients,and enhance their quality of life.
Keywords：lung cancerchemotherapychemotherapy-induced peripheral neuropathypotential profile analysisinfluencing factors
Publication Date：2026-02-15
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 417-421 )