Analysis of international research hotspots for Mendelian randomization in the field of depression
XU Mingjie
XIONG Yi
WEN Dan
YAN Yi
ZHAN Weixi
WU Dongmei
KONG Di
Abstract：Objective:To explore the status quo and research hotspots of Mendelian randomization(MR)studies in the field of depression.Methods:Taking the Web of Science Core Collection database as the data source,relevant literature on the application of MR in the study of depression from 2014 to 2024 were retrieved and visualized for analysis.Results:A total of 606 documents were retrieved,and the related research entered a stage of rapid development in 2022.Internationally,a relatively stable network of cooperative relationships among countries and institutions has been formed.The research hotspots of MR in the field of depression included exploring the causal relationship between depression and other diseases(cardiovascular diseases,cancer,inflammation),as well as the genetic mechanism and biomarker(IL-6,CRP)research of depression.Conclusions:Bibliometric analysis has demonstrated the research trend of MR in the field of depression.Foreign countries started early in this research field.Although China has published the largest number of papers in recent years,international exchanges and cooperation are scarce,and the cooperation between institutions and authors needs to be further strengthened.In the future,MR methods will provide a deeper understanding of the complexity of depression and offer more effective guidance for clinical practice.
Keywords：depressive disorderMendelian randomizationvisual analysisbibliometricsCiteSpace software
Publication Date：2025-11-15
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：6( 4014-4019 )