Effects of non-pharmacological interventions on improving fatigue in patients with systemic lupus erythematosus:a network Meta-analysis
LI Yuwei
SONG Weiting
LI Ke
WANG Sa
QIAO Caicai
MIAO Huali
Abstract：Objective:Using the network Meta-analysis method to evaluate the effect of different non-pharmacological interventions on improving fatigue in patients with systemic lupus erythematosus,in order to provide reference for nursing practice to improve fatigue status in patients with systemic lupus erythematosus.Methods:Computer searches of PubMed,the Cochrane Library,ScienceDirect,Medline,Embase,CNKI,VIP Database,Wanfang Database,and China Biomedical Literature Database were conducted from database establishment to June 2024.Stata17.0 was used for a network Meta-analysis.Results:A total of 17 RCT studies were included,including 7 non-pharmacological intervention methods.The results of the network Meta-analysis showed that exercise intervention,nutritional intervention,and acupuncture therapy had better effects on improving fatigue in patients with systemic lupus erythematosus than conventional nursing(P＜0.05).Among the 7 non-pharmacological interventions included,exercise intervention was superior to other interventions except for nutritional intervention(P＜0.05),while nutritional intervention was superior to health education,lifestyle intervention,and psychological intervention(P＜0.05).Area ranking under the cumulative ranking probability chart:exercise intervention＞nutritional intervention＞acupuncture therapy＞percutaneous vagus nerve stimulation＞health education＞lifestyle intervention＞psychological intervention＞routine nursing.Conclusions:Based on the results of the network meta-analysis and probability ranking,in the absence of contraindications to exercise,it is recommended that the clinical preferred exercise intervention be a non-pharmacological intervention to alleviate fatigue in patients with systemic lupus erythematosus,followed by nutritional intervention or acupuncture therapy.
Keywords：systemic lupus erythematosusfatiguenetwork Meta-analysisnon-pharmacological interventions
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 595-600 )