Fluid resuscitation management in children with septic shock:a summary of the best evidence

HU Yanli; CHEN Ou; HU Kuona; LYU Fangfang; XU Weijuan

doi:10.12104/j.issn.1674-4748.2025.03.003

Abstract：Objective:To summarize the best evidence for fluid resuscitation management in children with septic shock and provide reference for clinical practice.Methods:Related clinical decision support systems,guidelines,evidence summaries,evidence-based practices,expert consensus,systematic reviews,and meta-analyses on fluid resuscitation in children with septic shock were retrieved systematically from the clinical decision support system,guidelines website,professional association website,evidence-based database,and comprehensive database.The search period was from database establishment to May 1,2024.Two researchers who had learned evidence-based methods independently evaluated the quality of the literature,extracted,integrated and graded the included literature.An expert group was established to recommend the strength of the evidence.Results:A total of 13 papers were included,including 4 clinical decision articles,4 guidelines,4 expert consensus articles,and 1 evidence summary.A total of 17 pieces of evidence were summarized from five aspects:diagnosis of septic shock,early screening and identification,fluid resuscitation strategy,assessment and monitoring of resuscitation,and quality promotion.Conclusions:This study summarized the best evidence for fluid resuscitation management of septic shock in children,and suggested that clinical reference should be made in this study to build a localized practice plan,constantly update the best evidence,and improve the level of treatment and nursing.