Clinical study on influence of postoperative early rewarming on immune function of patients with l iver cancer
Abstract：Obj ective:To probe into the influence of different rewarming time on immune function of liver cancer patients complicated with hypothermia af-ter hepatectomy.Methods:A total of 90 cases of hypothermia patients were randomly divided into 3 groups according to the rewarming time:A group(<30 min),B group(30 min to 60 min)and C group(>60min),30 cases in each. The plasma IL 2 and IL 6 were measured on preoperative and postopera-tive 1st,2th day;and T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+) were measured on preoperative and postoperative 1st,5th day.Results:CD3+,CD4+ on the 1st day after operation and CD4+/CD8+ on 5th day were the lowest in group C(P<0.05).T cell subsets repeated analysis of variance in three groups of patients showed that the time effect,interaction effect and CD3+,CD4+,CD4+/CD8+ between group effect in all indexes were different (P<0.05).There was no difference in CD8 + in all groups before and after surgery and comparison between groups(P>0.05).On the postoperative 1st and 2th day,IL 2 was the lowest in group C;IL 6 was the highest in group C on the postoperative 2th day (P<0.05).There was between group effect in IL 2,the between group effect,time effect and interaction effect in IL 6 P<0.05.Conclusion:The rewarming time was longer than 60min,which would delay the recovery of immune function.Early postoperative effective rewarming can reduce immunosuppression and is profit for postoperative re-covery of patients.
Keywords：liver neoplamashypothermiarewarmingimmunity function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2040-2043 )