Probe into medication timing of acetaminophen for prevention of zoledronic acid adverse reaction
Chen Chuxian
Peng Songlin
Zhao Jian
Abstract：Obj ective:To probe into the best medication timing of acetamino-phen for prevention of zoledronic acid adverse reaction.Methods:A total of 60 cases of patients with postmenopausal osteoporosis were randomly divided into observation group and control group,30 cases in each.At 1 h before intrave-nous infusion of zoledronic acid inj ection in observation group and at 1 h after intravenous infusion in control group,the patients were given oral acetamino-phen sustained release tablets,oral acetaminophen were administered once a-gain respectively after interval 6 h and the next day in two groups.The adverse reactions were evaluated with TESS (TESS).Results:three ratings periods in-cluding 4 h,8h and the 2nd day after the use of zoledronic acid injection,the TESS score in observation group was lower than that in control group (t= -7.087,-4.777 and -5.087,P<0.01).Conclusion:acetaminophen used before intravenous infusion of zoledronic acid inj ection using can effectively prevent adverse effects of zoledronic acid,and its effect is better than that after intrave-nous administration.
Keywords：osteoporosisacetaminophenzoledronic acidadverse reactionsmedication timing
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1441-1442 )