Prediction of Alternative Splicing of Exons Based on Multi-features Fusion
YUAN Fang
FAN Jinping
Abstract：Lternative splicing is a regulated process during gene expression that results in a single gene coding for multi‐ple proteins .Identification of alternative splicing has important significance in the study of life and medical science .Due to the inherent limitations of alternative splicing ,the existing method of predicting alternative splicing can only suit for special alternative splicing cases .Here ,in addition to sequence inherent characteristics ,the nucleotide conservation is studied based on the characteristics .Combined with support vector machine ,a new model is established to predict the alternative splicing of exon .And ,the test results show that the performance of CDGMiner is satisfactory .
Keywords：alternative splicing of exonsupport vector machineconservative score statistics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2059-2062,2065 )