Effects of mediterranean diet combined with insulin pump therapy on glycemic control,pancreatic β-cell function,and quality of life in type 2 diabetes patients with abdominal obesity
LV Zhuan
ZHANG Jingjing
FANG Jiajia
QIU Jiaona
Abstract：Objective To investigate the effects of Mediterranean diet(MD)combined with continuous subcutaneous insulin infusion(CSII)on glycemic control,pancreatic β-cell function,and quality of life in type 2 diabetes mellitus(T2DM)patients with abdominal obesity.Methods A prospective study was conducted on 160 T2DM patients with abdominal obesity admitted to our hospital from January 2023 to January 2025.Participants were randomly assigned to control group(n=80,receiving CSII plus conventional diabetic diet)or intervention group(n=80,receiving CSII plus MD).Parameters including glucose metabolism(fasting plasma glucose[FPG],2-hour postprandial glucose[2hPG],glycated hemoglobin[HbA1c]),lipid profiles(low-density lipoprotein cholesterol[LDL-C],high-density lipoprotein cholesterol[HDL-C]),pancreatic function(HOMA-β,HOMA-IR),anthropometric indices(BMI,waist circumference,waist-to-hip ratio),Diabetes-Specific Quality of Life Scale(DSQL)scores and complication rates were compared.Results Repeated measures ANOVA showed significant time,group and interaction effects for 2hPG,HbA1c,LDL-C,HDL-C,HOMA-β and HOMA-IR(P<0.05),and significant time and group effects for FPG(P<0.05).After 3-month intervention,both groups showed significant improvements in BMI,waist circumference and waist-to-hip ratio compared to baseline,with greater improvements in the intervention group(t=4.508、5.074、3.614,P<0.05).The intervention group also demonstrated superior DSQL scores across all dimensions(t=4.206、4.025、5.007、4.303,P<0.05).Conclusion MD combined with CSII synergistically ameliorates glucolipid metabolism through β-cell function enhancement and insulin resistance reduction,while significantly ameliorating abdominal obesity and quality of life in T2DM patients.
Keywords：mediterranean dietinsulin pumptype 2 diabetes mellitusabdominal obesityglucose metabolism
Publication Date：2026-01-30
Online Publishing Date：2026-01-27(First online date of this platform, not the publication date of the document)
Pages：5( 64-68 )