Changes and clinical significance of serum NLR,IL-17,and MIP-1α in elderly patients with chronic pulmonary heart disease and heart failure
HUO Hongqiu
SONG Jinyu
YANG Jing
HE Honghong
FENG Baojing
Abstract：Objective To analyze the changes and clinical significance of serum neutrophil to lymphocyte ratio(NLR),interleukin-17(IL-17),and macrophage inflammatory protein-1alpha(MIP-1α)in elderly patients with chronic pulmonary heart disease(CPHD)and heart failure.Methods A total of 236 patients with CPHD who visited the hospital from January 2022 to December 2024 were selected as the research subjects.According to the diagnostic criteria for heart failure,they were assigned to the heart failure group(with heart failure,n=78)and the pure CPHD group(without heart failure,n=158).The patients'clinical data(gender,age,body mass index(BMI),smoking history,drinking history,course of CPHD,etc.)and various laboratory examination data(serum creatinine,blood urea nitrogen,serum NLR,IL-17,MIP-1α,etc.)upon admission were collected.Pearson's correlation was used to investigate the relationship between serum NLR,IL-17,MIP-1α and cardiac function indicators.The receiver operating characteristic(ROC)curves were used to evaluate the diagnostic efficacy of serum NLR,IL-17,and MIP-1α for heart failure in elderly patients with CPHD.Results The levels of NLR,LVEF and SV in the heart failure group were lower than those in the pulmonary heart disease group,while the levels of IL-17 and MIP-1α were higher than those in the pulmonary heart disease group(P<0.05).Pearson correlation analysis found that serum NLR,IL-17,and MIP-1α were negatively correlated with left ventricular ejection fraction(LVEF)and stroke volume(SV)in elderly patients with CPHD and heart failure(P<0.05).Logistic regression analysis found that LVEF and SV were protective factors for heart failure in elderly patients with CPHD,while serum NLR,IL-17,and MIP-1α were risk factors(P<0.05).ROC curve analysis showed that area under the curve(AUC)and sensitivity of combination of serum NLR,IL-17 and MIP-1α for diagnosing heart failure in elderly patients with CPHD were relatively higher(P<0.05).Conclusion The changes in serum NLR,IL-17,and MIP-1α play an important role in the pathological process CPHD with heart failure in the elderly.These indicators exhibit high diagnostic value.
Keywords：chronic pulmonary heart diseaseheart failureelderlyneutrophil to lymphocyte ratiointerleukin-17macrophage inflammatory protein-1alph
Publication Date：2026-01-30
Online Publishing Date：2026-01-27(First online date of this platform, not the publication date of the document)
Pages：4( 42-45 )