Research on the mediating effect of social activity participation on sarcopenia complicated with cognitive impairment
CHEN Sijia
YAN Jin
LU Tingting
WANG Linghuan
SUN Naiyuan
SHEN Xiaoying
KANG Na
YIN Huijia
FAN Li
CAO Feng
Abstract：Objective This study aims to explore the role of social activity participation in improving sarcopenia and cognitive function.Methods Based on the open-source database of the China Health and Retirement Longitudinal Study(CHARLS),6,463 individuals aged over 45 were included.Sarcopenia was assessed using the Asian Working Group for Sarcopenia(AWGS)criteria,and cognitive function was evaluated with the Mini-Mental State Examination(MMSE).The Baron and Kenny mediation model,together with Bootstrap method,were used to analyze the mediating effect of social activity participation on the relationship between sarcopenia and cognitive function.Results Baseline data showed that 827 participants had sarcopenia,with an overall prevalence of 12.8%.Correlation analysis revealed that social activity participation was negatively correlated with sarcopenia(r=-0.131,P<0.001),sarcopenia was negatively correlated with cognitive function(r=-0.232,P<0.001),and social activity participation was positively correlated with cognitive function(r=0.242,P<0.001).Mediation analysis revealed that,compared to the non-sarcopenia group,individuals with sarcopenia had a 1.041-point lower total cognitive score.Specifically,sarcopenia indirectly affected cognitive impairment by reducing social activity participation,accounting for 10.08%of the total effect(indirect effect β=-0.105,P<0.001).Conclusion Sarcopenia is significantly associated with cognitive decline,and the increased social activity participation can partially mitigate the mediating effect of sarcopenia on cognitive impairment.
Keywords：sarcopeniasocial activitycognitive functionmediation effectmiddle-aged and elderly people
Publication Date：2025-12-31
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：5( 1074-1078 )