Study on the rationality of prophylactic use of antimicrobial drugs in the elderly with class Ⅰ surgical incisions in a hospital and its relationship with surgical site infection
LI Jiaojiao
SONG Rui
ZHONG Yuting
Abstract：Objective To investigate the rationality of prophylactic use of antimicrobial drugs in the elderly with class I surgical incisions in clinical settings,and analyze the relationship between prophylactic use of antimicrobial drugs and surgical site infection.Methods Clinical data of 1,002 elderly patients with class I surgical incisions who were discharged from Sixian People's Hospital in 2023 were retrospectively collected.The prophylactic use rate of antimicrobial drugs,types of antimicrobial drugs,irrational drug use,and postoperative incision infection were analyzed.Univariate and multivariate logistic regression analyses were used to analyze the relationship between prophylactic use of antimicrobial drugs and surgical site infection.Results The prophylactic use rate of antimicrobial drugs in elderly patients with class I surgical incisions was 16.97%(170/1 002),and cefuroxime sodium was the main antimicrobial drug used(88.89%).The rational rate of prophylactic use of antimicrobial drugs was 17.65%(30/170),and there were 247 cases of irrational drug use,mainly including inappropriate timing of prophylactic use(38.46%)and long duration of prophylactic use(25.51%).The postoperative incision infection rate in elderly patients with class I surgical incisions was 3.59%(36/1 002).Multivariate logistic regression analysis results showed that duration of surgery,foreign body implantation,length of hospital stay,prophylactic use and rationality of antibiotics were independent risk factors for postoperative incision infection(P<0.05).Conclusion The irrational use of antimicrobial drugs in elderly patients with class I surgical incisions mainly include inappropriate timing of prophylactic use and prolonged duration of prophylactic use.Suboptimal prophylactic use of antimicrobial drugs may increase the risk of surgical site infection in elderly patients.Clinical practice should improve the rational rate of prophylactic use of antimicrobial drugs to reduce the risk of infection.
Keywords：class I incision surgeryantibacterial drugrational drug usesurgical site infection
Publication Date：2025-12-31
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：4( 1070-1073 )