Analysis of serum β-HCG,E2,D-D and AMH levels in the diagnosis of adverse pregnancy outcomes in high-risk pregnant women

ZHANG Xin; WEI Lihua; MA Guowei

doi:10.3969/j.issn.1674-3245.2025.06.026

Abstract：Objective To investigate the serum levels of β-HCG,E2,D-D and AMH in pregnant women with high-risk pregnancy,and evaluate their value in diagnosing adverse pregnancy outcomes in pregnant women through logistic regression and ROC curve.Methods The observation subjects were 306 pregnant women with high-risk pregnancy,treated from March 2021 to March 2023 in the observation group.The control subjects were 300 normal pregnant women at the same time as the observation group,and the group was the control group.β-HCG,E2,D-D and AMH level were measured,use logistic regression analysis to establish regression equation,and make the ROC curve of β-HCG,E2,DD and AMH to detect adverse pregnancy outcome.Results Among 306 high-risk pregnant women,84 cases of adverse pregnancy outcomes occurred.The β-HCG,E2 and AMH levels of the observation group were lower than those of the control group,and the D-D level was higher than that of the control group(t=35.410,150.331,121.873,11.442,P<0.05).The area under the ROC curve,sensitivity,specificity,and accuracy of the combined detection of high-risk pregnancy and adverse pregnancy outcomes for the combined detection of β-HCG,E2,DD,and AMH are significantly higher than those of the four single indicators.The cut-off value of β-HCG is 5 053.32 mIU/mL,the cut-off value of E2 is 610.65 pg/mL,the critical value of D-D is 873.08 pg/L,and the critical value of AMH is 2.09 ng/mL.Conclusion The sensitivity,specificity,and accuracy of the combined detection of β-HCG,E2,D-D and AMH in predicting adverse pregnancy in high-risk pregnancy patients are significantly higher than those of the single index detection of the four.The combined detection can predict adverse pregnancy outcomes of high-risk pregnant women.