Efficacy of comprehensive rehabilitation combined with enalapril maleate folic acid tablets and donepezil hydrochloride in the treatment of h-type hypertension with mild cognitive impairment

YANG Juan; TAN Chunlei; GE Lu

doi:10.3969/j.issn.1674-3245.2025.06.009

Abstract：Objective To observe the efficacy of comprehensive rehabilitation combined with enalapril maleate folic acid tablets and donepezil hydrochloride in the treatment of H-type hypertension with mild cognitive impairment(MCI).Methods Fifty-nine patients with H-type hypertension with MCI over 60 years of age admitted to Qixia District Hospital of Nanjing City from January 2023 to June 2024 were selected and randomly divided into two groups using a computer-generated randomization sequence in Microsoft Excel table.The control group was given enalapril maleate folic acid tablets with donepezil hydrochloride for treatment,and the comprehensive group added comprehensive rehabilitation therapy to the control group's program.The two groups were compared in terms of 24 h ambulatory blood pressure,homocysteine(Hcy),high-sensitivity-C-reactive protein(hs-CRP),the score of the Mini-Mental State Examination(MMSE),Wei-style Memory Scale(WMS-RC)score,Hasegawa Dementia Scale(HDS)score,and changes in the score of the ability to perform activities of daily living(ADL)to statistically measure the efficacy of the two groups in terms of blood pressure treatment.Results Comparison of the 24-hour dynamic blood pressure situation before treatment between the two groups was conducted;the difference is not statistically significant(P>0.05).The 24h dynamic blood pressure of both groups after treatment was lower than that before treatment,and the comprehensive group was lower than the control group after treatment(P<0.05).Comparison of Hcy and hs-CRP before treatment in the two groups showed no statistically significant difference(P>0.05).Hcy and hs-CRP were lower than before treatment in both groups after treatment,and were lower in the comprehensive group than in the control group after treatment(P<0.05).Comparison of WMS-RC scores before treatment between the two groups showed no statistically significant difference(P>0.05).Picture recall scores,associative learning scores,back-counting scores,and comprehension memory collocations were higher in both groups after treatment compared with before treatment,and were higher in the integrated group than in the control group after treatment(P<0.05).Comparison of HDS scores,MMSE scores,and ADL scores before treatment between the two groups showed no statistically significant difference(P>0.05).HDS scores,MMSE scores,ADL scores of both groups after treatment were higher than before treatment,and the comprehensive group was higher than the control group after treatment(P<0.05).The total effective rate of blood pressure in the composite group was 93.10%higher than 73.33%in the control group in comparison,and the difference was statistically significant(P<0.05).Conclusion Comprehensive rehabilitation combined with enalapril maleate folic acid tablets and donepezil hydrochloride for the treatment of H-type hypertension with MCI improves efficacy,blood pressure and cognitive function.