Evaluation value of prognostic nutritional index and advanced lung cancer inflammation index for the short-term efficacy of immune checkpoint inhibitors in the treatment of advanced non-small cell lung cancer
DU Yuexia
YONG Xiaofei
YANG Aixia
Abstract：Objective To analyze the predictive value of prognostic nutritional index(PNI)and advanced lung cancer inflammation index(ALI)for the short-term efficacy of first-line immune checkpoint inhibitors in the treatment of advanced NSCLC patients without driver gene mutations.Methods The data of 141 NSCLC patients treated at 940 Hospital of the Joint Logistics Support Force from January 2022 to March 2024 were analyzed.Patient demographic characteristics,clinical staging,Eastern Cooperative Oncology Group score,metastasis site,etc.,were organized;PNI and ALI were calculated.Divide patients into high PNI group,low PNI group,high ALI group,and low ALI group,and compare the disease control(DCR)rates of different PNI and ALI groups.Based on the recent efficacy of the patient,conduct a multiple-factor analysis to analyze the influencing factors of DCR,and draw ROC curves to compare and analyze the predictive value of the area under the curve(AUC)for ALI and PNI.Results Among the 141 patients,there were 0 CRs,34 PRs,67 PRs,and 40 PDs,with a DCR rate of 71.63%.According to the cut-off value of the ROC curve,patients were divided into the high PNI group,the low PNI group,the high ALI group,and the low ALI group.The DCR rate of the high PNI group was 86.45%,which was higher than that of the low PNI group(42.85%)(χ2=28.306,P<0.001).The DCR rate of the high ALI group was 85.43%,which was higher than that of the low ALI group(34.21%)(χ2=35.846,P<0.001).Multivariate analysis showed that staging,number of distant metastasis sites,PNI,and ALI were independent influencing factors on the efficacy of ICIs.The Youden indices for ALI,PNI,and their combination are 0.496,0.422,and 0.571,respectively;the AUC values are 0.754,0.696,and 0.791.Conclusion The relationship between nutrition,inflammation status,and the short-term efficacy of ICIs first-line treatment in advanced NSCLC patients is closely related.The higher the PNI and ALI,the better the prognosis of patients.Compared with PNI,ALI has a higher predictive value,and the combined predictive value of the two is higher than that of single prediction.
Keywords：prognostic nutritional indexadvanced lung cancer inflammation indeximmune checkpoint inhibitorsnon-small cell lung cancerprognosis
Publication Date：2025-12-31
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：5( 958-962 )