A preliminary study on risk of chronic obstructive pulmonary disease in population with preserved ratio impaired spirometry
ZHU Liqin
XIAO Lin
FENG Ying
YAN Jingxia
JIANG Dudu
CAO Huifang
Abstract：Objective To preliminarily explore the risk of chronic obstructive pulmonary disease(COPD)in population with preserved ratio impaired spirometry(PRISm).Methods From July 2024 to January 2025,289 consecutive subjects were recruited from Shanghai Jing'an District Central Hospital as study participants.According to lung function,the above 289 subjects were divided into PRISm group(n=93),healthy control group(n=116)and COPD group(n=80).The general data,lung ventilation function,bidirectional chest computed tomography(CT)and impulse oscillometry lung function were compared among the three groups.Correlation analysis between demographic characteristics,pulmonary ventilation function,bidirectional chest CT,impulse oscillometry pulmonary function and the occurrence of chronic obstructive pulmonary disease was conducted using collinearity diagnosis analysis and multivariate Logistic regression analysis model.Results There were significant differences among the three groups in terms of age,body mass index(BMI),chronic obstructive pulmonary disease screening questionnaire(COPD questionnaire),chronic obstructive pulmonary disease assessment test(CAT),proportion of smoking,smoking index,proportion of family history of respiratory diseases,proportion of second-hand smoke exposure,proportion of biofuel exposure history,among the three groups were statistically significant(F=313.458、240.856、1334.698、3213.604、489.823,χ2=37.346、9.354、35.139、23.841,P<0.05).percentage of forced expiratory volume in the first second(FEV1)to the predicted value,percentage of forced vital capacity(FVC)to the predicted value,FEV1/FVC,percentage of maximum mid-expiratory flow rate(MMEF)to the predicted value,percentage of forced expiratory flow of 50%vital capacity(FEF50%)to the predicted value,percentage of forced expiratory flow of 75%vital capacity(FEF75%)to the predicted value,percentage of total airway resistance(R5)to the predicted value,percentage of central airway resistance(R20)to the predicted value and MLDE/I(F=694.699、470.786、510.356、935.992、1533.161、1375.779、846.651,P<0.05).Through the analysis of collinearity and the multi-factor Logistic regression model analysis,age,smoking,smoking index,family history of respiratory diseases,exposure to second-hand smoke,and exposure to biofuels were positively correlated with the occurrence of chronic obstructive pulmonary disease(P<0.05);while BMI was not significantly correlated with the occurrence of chronic obstructive pulmonary disease(P>0.05).Conclusion Many indicators of pulmonary ventilation function,bidirectional chest CT,and pulse oscillation lung function in PRISm patients have significantly changed.Therefore,in clinical practice,it is necessary to pay attention to the changes in lung function of the PRISm population and take active measures based on their clinical characteristics.
Keywords：preserved ratio impaired spirometrylung ventilation functionsymptom scorechronic obstructive pulmonary disease
Publication Date：2025-12-31
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：5( 953-957 )