Visualization analysis of related studies on tumor microenvironment in non-small cell lung cancer
SHI Jianquan
MA Teng
HUANG Xin
LIU Qiuyue
CAO Xiaoqing
Abstract：Objective Summarize the research hotspots and trends in the field of the tumor microenvironment(TME)and non-small cell lung cancer(NSCLC).Methods The studies related to the TME in NSCLC in the Web of Science Core Collection database from January 1,2014,to December 31,2024 were searched.Excel 2018 and CiteSpace 6.4.R1 software were used to perform bibliometric analysis on the included literature,including publication year,country of publication,journal of publication,authors,research institutions,keywords,and co-cited references.Results A total of 2 840 articles were included.The annual publication volume in this field exhibited an overall upward trend,with the citation frequency also increasing year after year.The country with the highest number of publications was China,followed by the United States and Italy.The institution that published the most was the French National Institute of Health and Medical Research(INSERM).The author with the highest number of publications and citation frequency was Zhou,Caicun.The journals with the highest publication volume and citation frequency were Frontiers in Immunology and Clinical Cancer Research,respectively.Keyword co-occurrence analysis reveals that the cellular components of the tumor microenvironment,spatiotemporal heterogeneity,and the regulatory mechanisms mediated by extracellular vesicles are research hotspots.Reference co-citation analysis revealed three main research directions:TME studies utilizing single-cell sequencing,bioinformatics analysis,and tumor xenograft models;basic research on TME related to KRAS and EGFR mutations,angiogenesis,and acquired resistance;and(3)clinical research on TME focusing on immune checkpoint inhibitors(e.g.,ipilimumab,pembrolizumab)and neoadjuvant chemotherapy combined with immunotherapy.Conclusion The bibliometric approach can clearly and intuitively reveal the research hotspots and trends of global non-small cell lung cancer and the tumor microenvironment.
Keywords：non-small-cell lung cancertumor microenvironmentbiblimetricsvisualization analysis
Publication Date：2025-12-31
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：6( 947-952 )