The correlation between Ox-LDL levels and prognosis and cognitive impairment in patients with ischemic stroke
CHEN Lin
ZHANG Jie
WANG Yu
DAI Lin
ZHANG Haiyan
MENG Yan
Abstract：Objective To analyze the relationship between oxidized low-density lipoprotein(Ox-LDL)levels and the severity of neurological impairment,prognosis,and cognitive dysfunction in patients with ischemic stroke.Methods A total of 179 ischemic stroke patients admitted to the stroke unit of Xingtai Central Hospital from January 2023 to June 2024 were enrolled.Serum Ox-LDL levels were measured at admission using a fully automated chemiluminescence analyzer via chemiluminescent immunoassay(CLIA),with a normal reference range of≤64.4 U/L.Neurological impairment severity was assessed using the National Institutes of Health Stroke Scale(NIHSS)at admission.Post-stroke cognitive impairment(PSCI)was evaluated at 6 months post-stroke using the Montreal Cognitive Assessment(MoCA),and daily living ability was assessed via the modified Barthel Index(MBI).Ox-LDL levels were compared across groups with varying neurological impairment severities,degrees of daily living ability recovery,and between PSCI and non-PSCI groups.Correlations between Ox-LDL levels and NIHSS scores,MBI,and MoCA scores were analyzed.Receiver operating characteristic(ROC)curves were used to evaluate the predictive value of Ox-LDL.Results Ox-LDL levels progressively increased with worsening neurological impairment:mild group[34 cases,(52.3±11.9)U/L],moderate group[81 cases,(79.6±18.2)U/L],and severe group[64 cases,(93.1±10.7)U/L].Admission NIHSS scores positively correlated with Ox-LDL levels(r=0.287,P<0.05).At 6 months,the Ox-LDL level in the PSCI group(97.3±16.8)U/L was significantly higher than in the non-PSCI group(62.4±15.1)U/L(t=14.633,P=0.000).MoCA scores negatively correlated with Ox-LDL levels(r=-0.489).The area under the ROC curve(AUC)for Ox-LDL in predicting PSCI was 0.697(95%CI:0.599～0.821).Conclusion Ox-LDL levels are associated with the severity of neurological impairment and the occurrence of post-stroke cognitive dysfunction in ischemic stroke patients.Early detection of Ox-LDL levels may help identify high-risk PSCI patients,enabling timely interventions to improve prognosis.
Keywords：oxidized low-density lipoproteinischemic strokeprognosispost-stroke cognitive impairmentnursing
Publication Date：2025-10-31
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：4( 863-866 )