Effects of aerobic combined with resistance exercise on blood glucose regulation and liver fat content in patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease
ZHAO Yu
KONG Yanhua
CHEN Shuxia
MU Jinglan
Abstract：Objective To analyze the effects of aerobic combined with resistance exercise on blood glucose regulation and liver fat content in patients with type 2 diabetes mellitus(T2DM)and non-alcoholic fatty liver disease(NAFLD).Methods In this study,a single-blind randomized controlled trial design was used to select 80 patients with T2DM and NAFLD who were admitted to Bozhou People's Hospital from August 2024 to January 2025 as the research objects.Random sequences were generated by computer software and hidden by the sealed envelope method.The patients were randomly divided into control group and observation group,with 40 cases in each group.The control group received routine interventions,while the observation group received aerobic combined with resistance exercise intervention on the basis of the control group's treatment.Both groups were intervened continuously for 12 weeks.The blood glucose indexes,body weight,blood lipid indexes,adipokines,liver fat content,visceral fat area,liver function indexes,and insulin function indexes were compared between the two groups before and after the intervention.Results After 12 weeks of intervention,the fasting blood glucose level,glycosylated hemoglobin level,body mass index,triglyceride level,low-density lipoprotein cholesterol level,leptin level,liver fat content,visceral fat area,alanine aminotransferase level,aspartate aminotransferase level,and fasting C-peptide level of the observation group were all lower than those of the control group,and the differences were statistically significant(t=4.137,8.087,2.626,8.280,4.870,5.313,7.614,12.594,7.797,6.944,2.005,P<0.05).The high-density lipoprotein cholesterol level,adiponectin level,and islet function of the observation group were all higher than those of the control group,and the differences were statistically significant(t=3.049,4.459,4.102,P<0.05).After intervention,liver fat content and visceral fat area were positively correlated with FPG and HbA1c in both groups(r=0.323,0.411,0.453,0.586,0.351,0.407,0.557,0.375,P<0.05).Conclusion Aerobic combined with resistance exercise has a good clinical effect on patients with T2DM and NAFLD.It can effectively regulate the blood glucose level and adipokine level of patients,reduce liver fat content,and improve liver function and insulin resistance.Therefore,clinical nurses can enhance the enthusiasm of patients to participate in exercise for a long time through individualized evaluation and precise education,so as to improve the therapeutic effect.
Keywords：aerobic exerciseresistance movementtype 2 diabetesnonalcoholic fatty liverblood glucoseliver fat content
Publication Date：2025-10-31
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：5( 819-823 )