Analysis of relationship between changes of autonomic nervous function and occurrence and development of coronary heart disease
WANG Hui
TAO Mei
YANG Penghui
Abstract：Objective To investigate the relationship between the occurrence and development of coronary heart disease(CHD)and changes in autonomic nervous function.Methods 125 CHD patients in the hospital from July 2023 to October 2024 were retrospectively selected and included in the observation group,and 60 non-CHD patients with similar symptoms were enrolled as the control group.All patients received 24-hour dynamic electrocardiogram examination after admission.Heart rate variability indexes[standard deviation of NN intervals(SDNN),root mean square of successive differences(RMSSD),standard deviation of average normal to normal(SDANN),percentage of difference between consecutive N-N intervals>50 ms(PNN50)]were compared between groups.According to different clinical subtypes of CHD patients,34 patients with stable angina pectoris(SAP)were assigned into the SAP group,and 54 patients with unstable angina pectoris(UAP)were included in the UAP group,and 37 patients with acute myocardial infarction(AMI)were selected as the AMI group.The differences in SDNN,RMSSD,SDANN and PNN50 were analyzed among the three groups.Point-biserial correlation analysis was adopted to explore the relationship between SDNN,RMSSD,SDANN,PNN50 and occurrence and development of CHD.Results Compared with the control group,the SDNN,RMSSD,SDANN and PNN50 in the observation group were lower(t=17.306,8.414,16.975,5.044,P<0.05).Point-biserial correlation analysis found that CHD occurrence was significantly negatively correlated with SDNN,RMSSD,SDANN and PNN50(r=-0.524,-0.504,-0.516,-0.423,P<0.05).There were obvious differences in SDNN,RMSSD,SDANN and PNN50 among different CHD subtype groups(F=24.456,6.789,17.892,9.738,P<0.05).Compared with the SAP group and the UAP group,the above indexes were lower in the AMI group.Point-biserial correlation analysis revealed a significant negative correlation between AMI occurrence and the above indexes(r=-0.546,-0.508,-0.511,-0.436,P<0.05).Conclusion The autonomic nervous function of patients with different clinical subtypes of CHD is quite different,and the more severe the lesion is,the lower the heart rate variability related to autonomic nervous function is.Heart rate variability has certain value on judging the occurrence and development of CHD.
Keywords：coronary heart diseaseautonomic nervous functiondynamic electrocardiogramheart rate variability
Publication Date：2025-10-31
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：4( 810-813 )