Clinical significance of serum sialoglycan 6 and alveolar surfactant protein expression in patients with idiopathic pulmonary fibrosis
WANG Jing
FU Ran
TIAN Xiaohong
HE Yuanqiang
WAN Yufeng
Abstract：Objective To observe the clinical value of Krebs von den Lungen-6(KL-6)and surfactant protein D(SP-D)in the early diagnosis and assessment of idiopathic pulmonary fibrosis(IPF)in patients.Methods 38 patients with idiopathic fibrosis who received treatment from January 2022 to October 2024 and 25 healthy adults recruited during the same period and matched with IPF patients in terms of age and gender were selected as the research subjects.Compare the serum KL-6 and SP-D levels between IPF group and the healthy control group,analyze the correlation between serum KL-6 and SP-D levels and lung function,HRCT scores in IPF patients.Results The serum KL-6 and SP-D levels in the IPF group were significantly higher than those in the healthy control group(t=7.889,7.245,P<0.05).KL-6 and SP-D are significantly positively correlated with CT scores(r=0.703,0.632,P<0.05).KL-6 is negatively correlated with FVC%pred,DLco%pred,and FEV1/FVC,the correlation coefficients are-0.314,-0.415,and-0.388,while SP-D is negatively correlated with FVC%pred,FEV1%pred,and DLco%pred,the correlation coefficients are-0.279,-0.322,and-0.384.The areas under the curves for KL-6,SP-D,and their combined diagnosis of IPF are 0.906,0.899,and 0.940,respectively.The cut-off value for diagnosing IPF with KL-6 is 527.3 U/mL,and the cut-off value for SP-D is 89.2 ng/mL.Conclusion The detection of serum KL-6 and SP-D levels holds certain value for the early detection of idiopathic pulmonary fibrosis.Monitoring changes in their levels may aid in evaluating treatment efficacy and adjusting therapeutic plans,thereby contributing to the management of IPF patients.
Keywords：idiopathic pulmonary fibrosiskrebs von den lungen-6surfactant proteindiagnosis
Publication Date：2025-10-31
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：4( 777-780 )