Clinical Effect of Progressive Early Rehabilitation Training Combined with Octreotide in Patients with Moderate to Severe Acute Pancreatitis

doi:10.3969/j.issn.1674-3245.2025.04.037

Abstract：Objective To investigate the clinical effect of progressive early rehabilitation training combined with octreotide in patients with moderate to severe acute pancreatitis (MSAP). Methods A total of 132 MSAP patients treated at the Affiliated Luhe Hospital of Capital Medical University from October 2022 to October 2024 were selected and randomly divided into a control group (66 cases) and an observation group (66 cases). Both groups received octreotide treatment. The control group received conventional rehabilitation training, while the observation group received progressive early rehabilitation training. The efficacy, time for main symptoms to return to normal, time for serum amylase and urine amylase to return to normal, quality of life scale (GQOLI-74) scores, C-reactive protein (CRP), and nutritional indicators [white blood cell count (WBC), hemoglobin (Hb), red blood cell count (RBC), platelet count (PLT)] were compared between the two groups. Results After treatment, the total effective rate of the observation group was 93.94%, which was higher than that of the control group (80.30%), with a statistically significant difference (χ²=5.469, P<0.05). After treatment, the time for flatus recovery [(4.27±1.33) days vs. (5.69±1.68) days], bowel sound recovery [(5.12±1.63) days vs. (6.57±2.13) days], defecation recovery [(4.77±1.03) days vs. (5.35±1.28) days], abdominal pain relief [(4.61±1.31) days vs. (5.52±1.54) days], nausea relief [(3.89±0.83) days vs. (4.59±0.96) days], serum amylase recovery [(5.83±1.78) days vs. (6.72±1.96) days], and urine amylase recovery [(4.65±1.13) days vs. (5.86±1.37) days] were all shorter in the observation group, with statistically significant differences (t=5.991, 4.392, 2.868, 3.657, 4.481, 2.731, 5.535, P<0.05). After treatment, the psychological function score [(66.28±5.34) points vs. (59.37±4.88) points], physical function score [(62.42±5.43) points vs. (55.46±4.28) points], material life score [(60.97±5.11) points vs. (54.64±4.07) points], and social function score [(61.83±5.77) points vs. (57.47±4.56) points] were all higher in the observation group, with statistically significant differences (F=7.760, 8.178, 7.872, 4.816, P<0.05). After treatment, the CRP level [(33.87±4.73) mg/L vs. (45.82±5.28) mg/L], WBC level [(5.37±1.14)×10⁹/L vs. (9.38±2.07)×10⁹/L] were lower in the observation group, while Hb level [(159.62±6.63) g/L vs. (142.38±6.27) g/L], RBC level [(5.38±0.82)×10¹²/L vs. (4.47±0.75)×10¹²/L], and PLT level [(257.34±12.39)×10⁹/L vs. (226.76±10.71)×10⁹/L] were higher in the observation group, with statistically significant differences (t=13.695, 13.786, 15.349, 6.653, 15.169, P<0.05). Conclusion Progressive early rehabilitation training combined with octreotide has a significant therapeutic effect on MSAP patients, can accelerate symptom improvement, improve quality of life, reduce inflammatory response, and improve nutritional status.