Investigation of the correlation between coagulation disorder score and in-hospital mortality in patients with acute respiratory failure
Sun Xifeng
Liang Zhonghua
Yan Ping
Li Li
Ma Yu
Abstract：Objective To investigate the relationship between coagulation disorder score and prognosis in patients with acute respiratory failure(ARF),and evaluate its clinical value in predicting in-hospital mortality.Methods A retrospective analysis was conducted on 412 ARF patients from Yilong County People's Hospital.The coagulation disorder score(0～6 points)was calculated based on platelet count,international normalized ratio(INR),and activated partial thromboplastin time(APTT).Logistic regression was used to analyze the relationship between the coagulation disorder score and in-hospital mortality.Receiver operating characteristic(ROC)curves were used to compare the predictive performance of this score with Sequential Organ Failure Assessment(SOFA)and Simplified Acute Physiology Score Ⅱ(SAPS Ⅱ).Results In-hospital mortality increased significantly with higher coagulation disorder scores(71.4％vs 19.6％)(P＜0.05).Multivariate analysis showed that higher coagulation disorder scores were significantly associated with increased risk of in-hospital mortality(OR=6.88,95％CI:3.92～12.06,P＜0.001).Each one-point increase in the score was associated with a 21％increase in mortality risk(OR=1.21,95％CI:1.15～1.27,P＜0.001).ROC curve analysis showed that the predictive performance of this score(AUC=0.759)was superior to both SOFA and SAPS Ⅱ scores(P＜0.05).Conclusion The coagulation disorder score can serve as an effective tool for predicting in-hospital mortality risk in ARF patients,with superior predictive performance compared to traditional scoring systems and advantages of simple clinical application.
Keywords：Acute respiratory failureCoagulation disorder scoreIn-hospital mortalityPrognosis
Publication Date：2025-08-31
Online Publishing Date：2025-09-24(First online date of this platform, not the publication date of the document)
Pages：5( 695-699 )