Risk nomogram based on contrast-enhanced ultrasonography and enhanced CT to predict the risk of 2-year recurrence after resection of hepatocellular carcinoma
Xu Zhaojian
Wang Yinping
Xu Dan
Gao Yun
Abstract：Objective To analyze the risk nomogram based on contrast-enhanced ultrasound and enhanced CT for predicting the risk of recurrence of hepatocellular carcinoma in 2 years after resection.Methods A total of 120 patients admitted from January 2022 to January 2023 who were treated for 2 years after resection were selected as the study subjects,and they were divided into recurrence group and non-recurrence group according to the pathological examination results;all patients underwent CEUS Examination and scanning and 64-MDCT scanner for scanning examination;logistic regression model was used to analyze the independent risk factors of contrast-enhanced ultrasonography and enhanced CT to evaluate the recurrence of hepatocellular carcinoma 2 years after resection,and draw a risk nomogram to predict hepatocellular carcinoma resection After 2-year recurrence model,the ROC curve was drawn to analyze the value of the risk nomogram model in predicting postoperative 2-year recurrence.Results The ultrasound scans of patients in the recurrence group showed that BI,AUC,and PI were significantly higher than those in the non-recurrence group[(23.84±7.54)vs.(20.13±6.55)、(6 565.84±1 048.43)v.s.(4 983.68±1 413.39)、(54.85±6.95)vs.(44.75±7.01)].Meanwhile,AS,TTP,and AT were significantly lower than those in the non-recurrence group[(0.67±0.21)vs.(0.81±0.26)、(23.45±2.38)vs.(25.86±1.98)、(0.68±0.17)vs.(1.02±0.31)].The differences were statistically significant(t=2.542,6.971,7.679,3.485,5.519,7.759,P＜0.05).In the recurrence group,the arterial phase enhancement rate,venous phase enhancement rate,were significantly higher than those in the non-recurrence group[(0.66±0.12)vs.(0.59±0.11)、(0.83±0.10)vs.(0.73±0.09)],with statistically significant differences(t=3.461,6.315,P＜0.05).Lesion margin smoothness rate,and lesion non-enhancement rate from enhanced CT scans(0.66±0.12,0.83±0.10,87.01％,92.08％)were significantly higher than those in the non-recurrence group(0.59±0.11,0.73±0.09,13.85％,9.30％),with statistically significant differences(x2=61.812,80.916,P＜0.05).High BI,low TTP,low AT,high AUC,and high PI from contrast-enhanced ultrasound were identified as independent risk factors for recurrence of hepatocellular carcinoma(HCC)at 2 years after resection(P＜0.05).Low arterial phase enhancement rate,low venous phase enhancement rate,marginal nodules,and lesion enhancement from enhanced CT were also independent risk factors affecting the recurrence of HCC at 2 years after resection(P＜0.05).When analyzing patients with recurrence of HCC at 2 years after resection using contrast-enhanced ultrasound,a risk nomogram can be effectively constructed using BI,AUC,PI,TTP,and AT indices.When analyzing patients with recurrence of HCC at 2 years after resection using enhanced CT,a risk nomogram can be effectively constructed using arterial phase enhancement rate,venous phase enhancement rate,marginal nodules,and lesion enhancement indices.The AUC of the risk nomogram models constructed by contrast-enhanced ultrasound and enhanced CT for predicting recurrence of HCC at 2 years after resection were 0.926 and 0.952,respectively(P＜0.05).Conclusion The risk nomogram model based on contrast-enhanced ultrasound and enhanced CT can effectively predict the recurrence of hepatocellular carcinoma 2 years after resection,and has high application value.
Keywords：Contrast-enhanced ultrasonographyEnhanced CTRisk nomogram2-year recurrence after hepatocellular carcinoma resection
Publication Date：2025-08-31
Online Publishing Date：2025-09-24(First online date of this platform, not the publication date of the document)
Pages：5( 654-658 )