Effect of extracorporeal phrenic nerve stimulation combined with load deep breathing rehabilitation training on clinical symptom scores, cardiopulmonary endurance, and pulmonary function in patients with COPD
Abstract：Objective: To analyze the effect of extracorporeal phrenic nerve stimulation combined with load deep breathing rehabilitation training on clinical symptom scores, cardiopulmonary endurance, and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods: A prospective study was conducted on 112 COPD patients admitted to Kaikang General Hospital from May 2020 to December 2023. The patients were randomly divided into a control group and an observation group, each with 56 cases. The control group received routine treatment, while the observation group received extracorporeal phrenic nerve stimulation combined with load deep breathing rehabilitation training on this basis. Changes in cardiopulmonary function indicators including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, maximum minute ventilation (VEmax), peak oxygen uptake (PeakVO2), and ventilatory equivalent for CO2 at anaerobic threshold (VE/CO2 at AT) were compared between the two groups. Changes in exercise tolerance, dyspnea level, and COPD Assessment Test (CAT) scores were also compared. Results: After treatment, the levels of FEV1, FVC, FEV1/FVC, VEmax, and PeakVO2 in the observation group were higher than those in the control group, while the VE/CO2 at AT level was lower, with statistically significant differences between the groups (t=18.955, 8.845, 4.857, 19.826, 15.527, 14.827, P<0.05). After treatment, the 6-minute walking distance of the observation group was greater than that of the control group, with a statistically significant difference (t=27.925, P<0.05). After treatment, the modified Medical Research Council dyspnea scale (mMRC), CAT score, and Saint George's Respiratory Questionnaire (SGRQ) scores of the observation group were lower than those of the control group, with statistically significant differences (t=19.826, 15.527, 14.827, P<0.05). Conclusion: Implementing extracorporeal phrenic nerve stimulation combined with load deep breathing rehabilitation training for COPD patients in the recovery phase can effectively improve cardiopulmonary function, enhance exercise tolerance and capacity, significantly alleviate symptoms such as dyspnea and cough, and improve patients' quality of life.
Keywords：Extracorporeal phrenic nerve stimulationLoad deep breathing rehabilitation trainingChronic obstructive pulmonary diseaseCardiopulmonary functionExercise tolerance
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 507-509 )