Platelet-rich plasma injection in robot-assisted total knee arthroplasty:a prospective randomized controlled trial
Ren Haichao
Zhao Runkai
Zhuang Yuan
Chen Jiying
Zhang Guoqiang
Abstract：Objective To evaluate the impact of intraoperative platelet-rich plasma(PRP)application on postoperative rehabilitation in robot-assisted total knee arthroplasty(TKA).Methods A prospective randomized controlled trial was conducted,enrolling 162 patients who underwent robot-assisted TKA at the First Medical Center of the PLA General Hospital between February 2023 and September 2023.Patients were randomly assigned to the experimental group(n=81,receiving PRP injection)and the control group(n=81).Outcome measures included the knee society score(KSS),the Western Ontario and McMaster Universities Osteoarthritis index(WOMAC),Short Form-36(SF-36)score,five-time sit-to-stand test,and incidence of adverse events.Follow-up assessments were performed at 2 weeks,6 weeks,3 months,and 6 months postoperatively.Results There was no significant difference in operative time between the two groups[(71.94±11.06)vs.(69.55±12.12),t=1.193,P=0.235].There was no significant difference of KSS score between the two groups at any follow-up time point.The WOMAC score in the experimental group were significantly lower at 2 weeks[(2.70±1.26)vs.(3.39±1.45),t=-2.387,P＜0.05)]and at 6 weeks[(2.47±1.27)vs.(3.19±1.20),t=-2.740,P＜0.05].At 3 months,the physical function score in the experimental group was lower than that in the control group[(7.83±7.10)vs.(11.49±7.78),t=-2.226,P=0.028].The SF-36 score in the experimental group was higher at 2 weeks(55.24±22.78)vs.(47.70±15.36),and the social functioning scores at 3 months was also higher than that in the control group(86.60±12.23)vs.(76.71±22.03)(t=2.226、2.252,P＜0.05).Regarding adverse events,one patient in each group experienced postoperative incision exudation(PRP group)or localized hematoma(control group),both of which resolved after outpatient treatment.There was no significant difference in adverse event rates between the two groups(P＞0.05).Conclusion The findings suggest that intraoperative PRP injection in robot-assisted TKA may improve certain aspects of postoperative knee function,though overall functional improvement is limited.Short-term benefits in pain relief may exist.PRP injection appears to be a potential adjunctive therapy for robot-assisted TKA.
Keywords：Robot-assistedTotal knee arthroplastyPlatelet-rich plasmaRehabilitation
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 471-476 )