Effects of edaravone dextrorphan combined with treadmill aerobic training on neurological function,cardiac function and cardiopulmonary endurance in patients with acute ischemic stroke
Ma Jing
Zhang Xiaoyan
Zheng Yingying
Wang Haiyan
Abstract：Objective To investigate the effect of edaravone dextrose combined with treadmill aerobic training on neurological function,cardiac function and cardiopulmonary endurance in patients with acute ischemic stroke(AIS).Methods A total of 96 AIS patients who were treated in our hospital from January 2024 to June 2024 were prospectively selected for the study,and were randomly assigned to control group(n=48)and combined group(n=48).The control group was treated with edaravone right camphor,and the combined group was treated with treadmill aerobic training on this basis.Both groups were received 4-week continuous treatment.The efficacy,neurological function[National Institutes of Health Stroke Scale(NIHSS)score],cardiac function[left ventricular ejection fraction(LVEF),cardiac index(CI),cardiac output(CO)],cardiopulmonary endurance[exercise duration(ED),6-minute walking test(6MWT),peak oxygen consumption(VO2 max)],lower limb Fugl-Meyer Assessment Scale(FMA-LE)score,Barthel Index(BI)score and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the combined group was 93.75％,which was higher than that of the control group(77.08％)(x2=5.352,P＜0.05).After treatment,the LVEF,CI,CO,ED,6 MWT,VO2 max,NIHSS score,FMA-LE score and BI score in the combined group were higher than those in the control group,the differences were statistically significant(t=3.940,4.672,6.417,3.918,4.832,3.327,8.832,12.890,10.207,P＜0.05).There was had no difference in the incidence of side effect between the two teams(x2=0.136,P＞0.05).Conclusion The combined use of edaravone right camphor and treadmill aerobic training in AIS patients demonstrates superior efficacy,which can effectively improve cardiac function and cardiopulmonary endurance,improve neurological function,lower limb motor ability and daily living ability,and may serve as a recommended clinical regimen.
Keywords：Edaravone dextrorphanolBicycle aerobic trainingAcute ischemic strokeNeurological functionCardiac functionCardiopulmonary endurance
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 452-455 )