Effects of edaravone dextran combined with ultra-early rehabilitation training on limb function and living ability of patients with acute cerebral infarction

Chen Yun; Ma Shuping; Guo Xiaojun

doi:10.3969/j.issn.1674-3245.2025.03.020

Abstract：Objective To observe the effects of edaravone dextran combined with ultra-early rehabilitation training on limb function and living ability of patients with acute cerebral infarction.Methods Ninety patients with acute cerebral infarction admitted to Funan County People's Hospital from January 2023 to June 2024 were selected and randomly divided into the rehabilitation group(45 cases)and the comprehensive group(45 cases)according to SPSS26.0 software.Both groups were given conventional treatment,the rehabilitation group was treated with ultra-early rehabilitation training intervention,and the comPrehensive group was treated with edaravone dextroamPhetamine on its basis.Cerebrovascular function,KeaP 1-Nrf2/ARE signalling Pathway related proteins,brain-derived neuroaffective factor(BDNF),γ-aminobutyric acid(GABA),pentraxin 3(PTX3),and high sensitivity-C-reactive protein(hs-CRP)were detected in the two groups,and the differences in the Fugl-Meyer(FMA)scores and Barthel indices of the two groups were evaluated,and the effective rates of the two groups were counted.Effective rate.Results Comparing before and after treatment,the cerebrovascular reserve capacity(CVR),mean flow velocity(MFV),and breath-holding index(BHI)of the two groups were elevated,and the pulsation index(PI)decreased(t=6.320,9.498,6.085,12.753,3.781,5.481,4.720,7.220,P＜0.05).After treatment,CVR,MFV and BHI were higher in the combined group than those in the rehabilitation group(t=3.223,6.169,2.024,4.561,P＜0.05).After treatment,nuclear factor-E2-related factor 2(Nrf2)and antioxidant response element protein(ARE)were elevated in both groups,and Kelch-like epoxychloropropamide-related protein 1(KeaP1)decreased(t=33.713,41.719,24.150,32.998,28.428,35.143,P＜0.05).Compared to the rehabilitation group after treatment,Nrf2 and ARE were higher and KeaP1was lower,in the integrated group(t=11.541,14.804,9.099,P＜0.05).While BDNF and GABA were elevated,PTX3 and hs-CRP were decreased in both groups(t=8.090,8.812,5.574,9.353,5.063,14.109,21.942,24.884,P＜0.05).BDNF and GABA were higher in the integrated group after treatment,while BDNF,GABA,PTX3,hs-CRP were lower than those in the rehabilitation group(t=5.070,3.614,9.236,5.377,P＜0.05).FMA score and Barthel index increased in both groups after treatment(t=16.390,25.343,11.393,16.889,P＜0.05).FMA score and Barthel index were higher in the comprehensive group than those in the rehabilitation group after treatment(t=7.527,5.286,P＜0.05).Compared with the rehabilitation group,the total effective rate in the integrated group was significant higher 91.11％(41/45)vs 75.56％(34/45),(x2=3.920,P=0.048).Conclusion Edaravone dextran combined with ultra-early rehabilitation improves limb function,living ability and cerebrovascular function in patients with acute cerebral infarction,which may be related to the regulation of KeaP1-Nrf2/ARE signalling pathway-related proteins.