Prognostic value of blood lactate,procalcitonin,and D-dimer in patients with AECOPD and respiratory failure
Sun Zhao
Liu Xueling
Cui Liangwen
Zhao Kui
Abstract：Objective To investigate the prognostic value of blood lactate(Lac),procalcitonin(PCT),and D-dimer(D-D)in patients with AECOPD and respiratory failure.Methods A total of 46 patients with AECOPD and respiratory failure(AECOPD+respiratory failure group)who were admitted to the Department of Critical Care Medicine at Funan County People's Hospital from January 2022 to June 2024 were retrospectively analyzed.According to the 28-day prognosis,patients were divided into survival group(n=36)and death group(n=10).Meanwhile,23 patients with respiratory failure of gender-and age-matched but without AECOPD(the respiratory failure group)were selected.Plasma Lac,PCT,and D-D levels in the two groups were compared.ROC curves were used to analyze the prognostic value of Lac,PCT,and D-D in patients with AECOPD and respiratory failure.Results Plasma levels of Lac,PCT,and D-D in the AECOPD combined with respiratory failure group[(2.93±0.37)mmol/L,(6.34±1.56)ng/ml,(4.28±1.05)mg/L]were higher than those in the respiratory failure[(2.65±0.30)mmol/L,(4.18±1.05)ng/ml,(3.62±0.93)mg/L](t=3.145,5.986,2.553,P＜0.05).Plasma levels of Lac,PCT,and D-D in the death group[(5.69±0.42)mmol/L,(9.35±2.33)ng/ml,(5.84±1.46)mg/L]were higher than those in the survival group[(2.16±0.27)mmol/L,(5.50±1.42)ng/ml,(3.85±0.88)mg/L](t=32.197,6.537,5.428,P＜0.05).Logistic regression analysis showed that Lac(OR=2.522,P=0.008),PCT(OR=1.374,P=0.013),and D-D(OR=1.579,P=0.017)were risk factors for death in patients with AECOPD and respiratory failure.The sensitivity and specificity of combination of the three indicators for predicting death in patients with AECOPD and respiratory failure were 93.33％and 91.55％(AUC=0.980,95％CI=0.951～1.000).Conclusion Lac,PCT,and D-D can serve as predictors in patients with AECOPD and respiratory failure,and may provided exhibit high predictive value for prognosis.
Keywords：Acute exacerbation of chronic obstructive pulmonary diseaseRespiratory failureBlood lactateProcalcitoninD-dimer
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 411-414 )