Prognostic value of advanced glycation end products for exercise ability improvement after cardiac rehabilitation in cardiovascular disease
Li Jing
Huang Xin
Wang Jing
Zhao Yaowei
Abstract：Objective To evaluate the association between skin autofluorescence(SAF),a biomarker of tissue advanced glycation end-product(AGE)accumulation,and post-cardiac rehabilitation(CR)exercise capacity improvement in cardiovascular disease(CVD)patients.Methods We retrospectively analyzed 99 CVD patients undergoing CR from February 2020 to April 2023.The 6-minute walk distance(6MWD),peak oxygen uptake(VO2)and anaerobic threshold(AT)were recorded at baseline and after 3 weeks of CR.Using the AGE Reader in patients with seat from baseline SAF level.Results According to the SAF level tertiles,the patients were divided into low level group(SAF level ≤ 2.56 a.u),medium level group(2.56 a.u＜SAF level≤3.37 a.u)and high level group(SAF level＞3.37 a.u).There were 33 patients in each group.There were no significant differences in baseline 6MWD,AT and peak VO2 levels among the high,middle and low level groups(P＞0.05).After 3 weeks of CR,6MWD(t=2.156,P＜0.05),AT(t=2.315,P＜0.05)and peak VO2(t=2574,P＜0.05)levels in the low level group were higher than those at baseline,but there were no significant changes in the middle level group and the high level group.In addition,the 6MWD(F=3.754,P＜0.05),AT(F=6.153,P＜0.05)and peak VO2(F=9.250,P＜0.05)levels of CVD patients in the low level group after 3 weeks of CR were also higher than those in the medium-level and high-level groups.By the Spearman rank correlation analysis,SAF level and 6 MWDS increase％(rs=0.436,P＜0.001),increased the AT％(r,=0.212,P=0.035),increased VO2 peak％(r,=0.297,P=0.003)were negative correlation,After age,sex and correction is still a negative correlation.Conclusion Baseline SAF levels of AGE accumulation in responding tissues were inversely associated with increases in 6MWD,AT,and peak VO2 after CR,indicating that lower baseline SAF levels predict greater CR-induced improvements in exercise capacity.
Keywords：Advanced glycation end productsCardiovascular diseaseCardiac rehabilitationExercise ability
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 391-395 )