Risk factors and prediction model construction for lower urinary tract dysfunction after holmium laser enucleation of prostate in patients with benign prostatic hyperplasia
Wang Chao
Qu Zhi
Li Haili
Zhang Liwen
Li Chenxi
Yang Lijun
Abstract：Objective To analyze the influencing factors of urinary tract dysfunction in patients with benign prostatic hyperplasia(BPH)after holmium laser enucleation(HoLEP),and to build a prediction model based on these factors.Methods The clinical data of 98 BPH patients who underwent HoLEP in Beijing Friendship Hospital Pinggu Campus from February 2021 to February 2024 were selected retrospectively analyzed.According to whether the patients had lower urinary tract dysfunction after operation,they were divided into obstacle group(n=31)and non-obstacle group(n=67).Multivariate Logistic regression was used to analyze the influencing factors of urinary tract dysfunction after operation,and ROC curve was used to evaluate the predictive value.Results The results showed that there were statistically significant differences between the two groups in body mass index(BMI),diabetes status,preoperative International Prostate Symptom Score(IPSS),C-reactive protein(CRP)levels,qualitative urine protein,presence of mucous stool,total protein(TP)levels,albumin(ALB)levels,globulin(GLO)levels,prostate-specific antigen(PSA)levels,total prostate volume(TPV),intravesical prostatic protrusion(IPP),resistance index(RI),detrusor wall thickness(DWT),detrusor pressure at maximum flow rate(Pdet Qmax),and maximum flow rate(Qmax)(P＜0.05).Logistic multivariate analysis showed that CRP,PSA,TP,ALB and Qmax were independent predictors of lower urinary tract dysfunction in BPH patients after HoLEP.The ROC results showed that the AUC of CRP,PSA,TP,ALB and Qmax for lower urinary tract dysfunction in BPH patients after HoLEP was 0.789,0.795,0.814,0.973,0.811 and 0.761,respectively,and the corresponding sensitivity was 87.59％and 66.37％.Conclusion CRP,PSA,TP,ALB and Qmax are independent predictors of lower urinary tract dysfunction in BPH patients after HoLEP.The prediction model constructed in this study has certainly clinical application value and can provide clinicians with scientific preoperative evaluation tools.
Keywords：Prostatic hyperplasiaHolmium laserProstate enucleationUrinary tract dysfunctionInfluencing factor
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 377-381 )