Correlation of intrinsic capacity decline and insomnia with body's nutritional status and low-grade inflammation in elderly inpatients
Quan Jing
Ning Yunyan
Huang Yan
Li Jing
Ma Ran
Liu Xiangyan
Zhang Li
Abstract：Objective To investigate the correlation of intrinsic capacity decline with insomnia,body' s nutritional status and low-grade inflammation in elderly inpatients.Methods The clinical case data of 248 elderly inpatients in the hospital were retrospectively analyzed from June 2022 to November 2023.The intrinsic capacity and sleep status[Pittsburgh Sleep Quality Index(PSQI)]were assessed,and the levels of serum albumin(ALB),prealbumin(PAB),interleukin(IL-1)and tumor necrosis factor(TNF-α)were detected.The differences in sleep status,nutritional status and chronic low-grade inflammatory factors were compared among patients with different intrinsic capacities.Pearson correlation analysis was used to explore the relationship between intrinsic capacity and insomnia,nutritional loss and chronic low-grade inflammation in patients.Results The levels of serum ALB and PAB in patients with internal capacity loss were significantly lower than those in patients with good internal capacity(t=8.512,5.130,P＜0.05)while the levels of IL-1 and TNF-a and PSQI score were significantly higher(t=6.981,8.100,12.642,P＜0.05).The intrinsic capacity score of patients was negatively correlated with serum ALB and PAB levels(r=-0.758,-0.698,P＜0.05),and was positively correlated with IL-1 and TNF-α levels and PSQI score(r=0.485,0.587,0.599,P＜0.05).Conclusion The intrinsic capacity of elderly inpatients is closely related to sleep quality,body' s nutritional loss and chronic low-grade inflammation.Therefore,actively improving the sleep quality and nutritional status and eliminating the chronic low-grade inflammation in clinical treatment can help prevent the loss of intrinsic capacity.
Keywords：Elderly inpatientsIntrinsic capacityInsomniaNutritional lossChronic low-grade inflammation
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 277-280 )