Study on the value of neostigmine combined with mirabilite external application and defecation training in intestinal function recovery after colorectal cancer surgery
Ji Jingjing
Yang Hongsheng
Yan Haihua
Abstract：Objective To study the value of neostigmine combined with mirabilite external application and defecation training for intestinal function recovery in patients with colorectal cancer after radical surgery.Methods A prospective selection was made from 102 postoperative patients with colorectal cancer at Hai'an People's Hospital from January 2020 to December 2023.They were randomly divided into an observation group and a control group using a random number table method.After operation,51 patients in the control group were given abdominal application of glauber nitrate combined with defecation training intervention,while 51 patients in the observation group received additional treatment with neostigmine.Compare inflammatory cytokine indicators between two groups[interleukin-6(IL-6),interleukin-1 β(IL-1 β)、Tumor necrosis factor-α(TNF-α)]、Gut mucosal barrier function related indicators[D-lactate(D-LA),diamine oxidase(DAO)],T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),Gastrointestinal Symptom Rating Scale(GSRS)score,and Wexner scores.Results After treatment,serum levels of IL-6,IL-1β and TNF-α in 2 groups were lower than before treatment.The observation group was lower than the control group[(38.57±6.37)pg/ml vs.(43.72±7.95)pg/ml,(38.06±7.92)pg/ml vs.(45.36±8.25)pg/ml,(18.49±5.52)pg/L vs.(24.96±6.72)pg/L],the difference was statistically significant(t=3.610,4.559,5.313,P<0.05).After treatment,serum D-LA and DAO levels in 2 groups were lower than before treatment,and the observation group was lower than the control group[(3.28±0.42)mmol/L vs(4.51±0.63)mmol/L,(3.86±0.55)IU/ml vs(5.14±0.62)IU/ml].The difference was statistically significant(t=11.601,11.029,P<0.05).After treatment,CD3+,CD4+and CD4+/CD8+in both groups were higher than before treatment.The observation group was higher than the control group[(67.25±6.23)%vs(61.94±5.86)%,(42.81±4.29)%vs(39.14±3.51)%,(1.82±0.26)vs(1.54±0.22)].The difference was statistically significant(t=4.434,4.728,5.871,P<0.05).After treatment,the GSRS and Wexner scores of the two groups were lower than before treatment,and the observation group was lower than the control group[(15.41±1.06)points vs(17.09±1.83)points,(7.12±2.06)points vs(9.37±2.25)points].The difference was statistically significant(t=5.673,5.267,P<0.05).Conclusion The combination of neostigmine and defecation training for postoperative colorectal cancer has good clinical effects,which is beneficial for reducing inflammatory reactions,improving the intestinal mucosal barrier function and immune function of patients,and improving their intestinal function.
Keywords：Radical surgery for colorectal cancerNeostigmineMirabiliteDefecation trainingIntestinal mucosal barrier function
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 151-155 )