Recombinant bovine basic fibroblast growth factor combined with triamcinolone acetonide for the treatment of hypertrophic scar
Chen Xinge
Liang Rong
He Qiuyue
Tang Ping
Gao Hu
Abstract：Objective To explore the clinical efficacy of recombinant bovine basic fibroblast growth factor(rb-bfGF)combined with triamcinolone acetonide in the treatment of hypertrophic scar(HS).Methods 174 HS patients admitted to Wuhan Third Hospital from February 2022 to January 2023 were prospectively selected as the study subjects.The patients were divided into three groups:the triamcinolone acetonide group(n=58),the rb-bfGF group(n=58),and the combination group(n=58).The triamcinolone acetonide group was treated with triamcinolone acetonide injection,the rb-bfGF group was treated with rb-bfGF,and the combination group was treated with a combination of triamcinolone acetonide and rb-bfGF.The vancouver scar scale(VSS)score,four-item itch scale(FIIQ)score and digital rating scale(NRS)were compared between the three groups,and the scar morphological changes and scar area changes before and after treatment were recorded.Epidermal growth factor(EGF),vascular endothelial growth factor(VEGF),interferon-γ(IFN-γ),tumor necrosis fact-α(TNF-α),occurrence of adverse reactions,and follow-up recurrence were compared.Results After treatment,the VSS score,FIIQ score,and NRS score in the combination group were lower than those in the dexamethasone group and rb-bfGF group,with statistical significance(F=12.341,4.364,8.834,P<0.05).The scar thickness and area were lower than those in the dexamethasone group and rb-bfGF group,with statistical significance(F=10.313,140.187,P<0.05).The average levels of EGF,VEGF,IFN-γ,and TNF-α were lower than those in the dexamethasone group and rb-bfGF group,with statistical significance(F=12.341,4.364,8.834,P<0.05).The incidence of adverse reactions and follow-up recurrence rate in the combination group were lower than those in the triamcinolone acetonide group and rb-bfGF group(4.034,3.826,7.900,5.641,P<0.05),and the difference was statistically significant(χ2=16.088,6.538,P<0.05),The efficacy evaluation of the combined group was better,and the difference was statistically significant(χ2=15.400,P<0.05).Conclusion rb-bfGF combined with triamcinolone in the treatment of hypertrophic scar is effective,better than triamcinolone alone,and less adverse reactions.
Keywords：Recombinant bovine basic fibroblast growth factorTriamcinolone acetonideThe hypertrophic scar
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 146-150 )