Effect of penehyclidine hydrochloride injection on organophosphorus poisoning
Guo Yanan
Wangchong
Zhaodong
Wang Hongyu
Abstract：Objective The application of penehyquidine hydrochloride injection(PHC)in the treatment of organophosphorus poisoning(OPP).Methods A total of 156 patients with OPP admitted to our hospital from January 2021 to December 2023 were enrolled and evenly divided into a control group and an observation group(78 each)through random draw.The control group received intravenous atropine,while the observation group was administered PHC via intramuscular injection.Clinical outcomes,recovery times,onset and duration of delirium,myocardial enzyme spectrum indices,and complications were compared between the two groups.Results The total effective rate in the observation group was 93.59%higher than that in the control group(χ2=7.620,P=0.006).The onset of mild,moderate and severe delirium in the observation group[(6.48±2.45)h,(9.48±1.36)h,(13.67±2.32)h]was longer than that in the control group(t=8.809,8.811,15.954,P<0.05).The duration of mild,moderate and severe symptoms in the observation group[(17.64±3.49)h,(13.69±3.26)h,(8.29±2.13)h]was longer than that in the control group(t=17.192,12.756,14.670,P<0.05).Lactate dehydrogenase(LDH)(116.79±22.34),creatine kinase isozyme-MB(CX-MB)(16.24±4.30)U/L,creatine kinase(CK)(102.47±27.49)U/L and hydroxybutyrate dehydrogenase(HBDH)(152.60±12.34)U/L were all lower in the observation group According to the group(t=5.785,4.990,3.748,7.615,P<0.05).The complication rate of 6.41%in the observation group was lower than 20.51%in the control group(χ2=6.658,P=0.010).Conclusion PHC shows unique advantages in OPP first aid,achieving accurate control of central symptoms,alleviating peripheral side effects,delaying the occurrence of delirium,reducing the risk of atropine poisoning,shortening hospitalization,ventilator use and CHE recovery time,reducing total complications,cardiac protection and improving overall treatment efficiency,which is of great value for OPP treatment.
Keywords：Penehyclidine HydrochlorideOrganophosphate PoisoningCholinesteraseAtropinizationAtropine Poisoning
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 126-130 )