Relationship between the distribution of traditional Chinese medicine syndrome patterns and nutritional status,lung function,acute exacerbation in patients with stable COPD

Gu Yijuan; Sun Min; Yang Ye

doi:10.3969/j.issn.1674-3245.2025.01.009

Abstract：Objective To investigate the relationship between the distribution of traditional Chinese medicine syndrome patterns and nutritional status,lung function,acute exacerbation in patients with stable chronic obstructive pulmonary disease(COPD).Methods Retrospective analysis of clinical data of 96 COPD patients admitted to our hospital from February 2022 to February 2024.They were assigned to the stable group(64 cases)and the acute exacerbation group(32 cases).Collect and compare two sets of general information and traditional Chinese medicine syndrome types,and test and compare the nutritional indicators and lung function indicators of the two groups;Use multiple logistic regression analysis to identify risk factors for acute exacerbation of COPD.Results The body mass index(BMI)of patients in the stable phase was(25.35±1.02)kg/m2,which was higher than that in the acute exacerbation phase(23.85±0.79)kg/m2(t=2.430,P=0.017).The proportion of patients with diabetes(20.31%)was lower than that in the acute exacerbation phase(46.88%)(χ2=7.286,P=0.007).The Chinese medicine syndrome types of patients in the stable phase included lung qi deficiency,lung spleen deficiency,lung kidney qi deficiency,and the acute exacerbation phase included phlegm heat obstructing the lung,and phlegm turbid obstructing the lung.The levels of serum albumin(ALB),prealbumin(PA),transferrin(Tf),forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and peak expiratory flow rate(PEF)in stable phase patients were(24.05±1.52)g/L,(111.25±16.38)mg/L,(1.80±0.32)g/L,(0.78±0.30)L,(1.82±0.36)L,and(3.85±0.85)L/s,respectively,which were lower than those in acute exacerbation phase patients(21.31±1.13)g/L,(86.25±13.65)mg/L,(1.61±0.29)g/L,(0.63±0.26)L,1.60±0.31)L,(3.42±0.72)L/s(t=9.018,7.434,2.827,2.410,2.951,2.454,P<0.05).Through multiple regression analysis,BMI,nutritional indicators,and lung function indicators are all risk factors for acute exacerbation in COPD patients(P<0.05).Conclusion BMI,nutritional level,traditional Chinese medicine syndrome patterns,and lung function are risk factors for acute exacerbation in patients with stable COPD.In clinical practice,patients'nutritional status and lung function should be evaluated in time,and corresponding measures should be taken for high-risk patients to improve nutrition,enhance lung function,and reduce the risk of acute exacerbation.