Correlation analysis of serum Asprosin,MIP-1β,25-(OH)D3 levels and osteoporosis complicating type 2 diabetes mellitus
Guo Xiaofang
Shen Yun
Yang Qianhong
Abstract：Objective To analyze the correlation between serum Asprosin,Macrophage Inflammatory Protein-1β(MIP-1β),and 25-hydroxyvitamin D3[25-(OH)D3]levels and type 2 diabetes mellitus complicated with osteoporosis.Methods The clinical data of 110 patients with type 2 diabetes mellitus admitted to Minhang Hospital of Fudan University from January 2022 to December 2023 were retrospectively analyzed and divided into concurrent and uncomplicated groups according to whether they were complicated with osteoporosis.General information and serum Asprosin,MIP-1β,25-(OH)D3 levels were compared between the two study groups,and risk factors for type 2 diabetes mellitus complicating osteoporosis were analyzed using logistic regression,and the predictive value was detected by using receiver operating characteristic curve(ROC).Results There were 48 patients in the complicated group and 62 patients in the uncomplicated group.Comparison of age,diabetes duration,serum Asprosin,MIP-1β,and 25-(OH)D3 levels between the two groups showed statistically significant differences(t=4.749,7.629,11.594,5.214,11.655,P<0.05).Logistic analysis showed that age(OR=1.508,95%CI=1.078～2.110),diabetes duration(OR=6.170,95%CI=1.341～28.398),serum Asprosin(OR=1.079,95%CI=1.012～1.150),MIP-1β(OR=1.021,95%CI=1.002～1.040),and 25-(OH)D3(OR=0.461,95%CI=0.246～0.862)were independent influences affecting the complication of osteoporosis in patients with type 2 diabetes mellitus(P<0.05).The area under the curve(AUC)of the ROC of serum Asprosin,MIP-1β,and 25-(OH)D3 alone for the occurrence of type 2 diabetes mellitus complicating osteoporosis was 0.711,0.756,and 0.821,respectively,and the AUC of the ROC of the combination of the three was 0.920,which was higher than that of the test alone(P<0.05).Conclusion Serum Asprosin,MIP-1 β and 25-(OH)D3 levels are correlated with type 2 diabetes complicated with osteoporosis.The combined detection of the three can provide a direction for the prevention and early diagnosis of type 2 diabetes complicated with osteoporosis,and provide a theoretical basis for the research of type 2 diabetes complicated with osteoporosis.
Keywords：AsprosinMIP-1β25-(OH)D3Type 2 diabetes mellitusOsteoporosis
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 773-777 )